Toll样受体4与动脉粥样硬化关系的研究进展

The relationship between toll-like receptor 4 and atherosclerosis

动脉粥样硬化是心脑血管疾病的病理基础。但目前关于动脉粥样硬化的发病机制还不是很清楚。普遍认为免疫应答，包括固有免疫和适应性免疫在动脉粥样硬化的发生发展中起了重要作用。Toll受体4（TLR4）是抗原相关分子模式（PAMP）受体，在识别微生物感染、激发先天性免疫反应中发挥了重要作用。近来发现炎症在动脉粥样硬化发展的各个阶段均发挥了重要作用，虽然目前确切的证据还缺乏，但是越来越多的调查发现，病原体感染引起的分子和细胞的改变表明炎症具有这种作用。

Atherosclerosis is the major cause of cardiovascular and cerebrovascular diseases. However, the precise pathogenesis of atherosclerosis has not been clarified now o It is widely accepted that,immune mechanisms,including inr, ate immunity and acquired immunity,play important roles in the process of atherosclerosis o Toll-like receptor 4 （TLR4） is a pathogen-associated molecular pattern receptor, which plays an important role in innate immune signaling in response to microbial infection. Recent researches have recognized the fundamental role of inflammation in mediating all stages of atherosclerosis. Although the definite proof of the role of infection corttributing to atherosclerosis is lacking, more and more researches have demonstrated that infectious agents evoke cellular and molecular changes.