肺泡表面活性物质(PS)对盐酸吸入性肺损伤的治疗进展

Progress of Pulmonary Surfactant in Treatment of the Second Phase ALI/ARDS Induced by Hydrochloric Acid Inhalation

急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)是临床上常见的危重症,治疗措施包括机械通气及药物综合治疗。肺泡表面活性物质(PS)在维持正常的肺功能起着重要作用,业已证明,PS异常与ALI/ARDS的发病有关,给予外源性PS亦可治疗ALI/ARDS。本文就外源性PS在盐酸吸入性ALI/ARDS的第二时相中的疗效及其可能的作用机制做一综述。

Acute lung injury / acute respiratory distress syndrome （ALI / ARDS） are common critical diseases in clinic. The treatment measures include mechanical ventilation and drug treatment. Pulmonary surfactant （PS） is important to maintain the normal lung function. It has been attested that PS alterations have been implicated in the pathophysiology ofALI / ARDS, and that exogenous PS can exert therapeutic effect on patients with ALI / ARDS. This article discussed the efficacy and its possible mechanism of pulmonary surfactant treatment in the second phase of hydrochloric acid inhalation induced ALI / ARDS.