摘要
人体是一种高度复杂的手性环境。手性药物用于机体后,两对映体与体内的大分子物质结合,呈现作用机制和结合力的差别,从而导致手性药物的体内立体选择性特征,产生药理学上的差别。二氢吡啶类钙通道阻滞剂具有舒张血管等重要作用,在临床上对治疗高血压等心脑血管疾病具有很好的临床应用价值。本文就以手性药物和钙通道阻滞剂的药效学立体选择性作一综述。
The human body is a highly complex chiral environment. After chiral drugs affect the body, two enantiomers bound to macromolecular show differences in aspect of mechanism and integration, resulting in the stereoselectivity characteristics of the chiral drug and differences in pharmacology. Dihydropyridines （DHPs） calciumchannel blockers （CCBs）, playing an important role in the relax- ation of blood vessel, have very good values in the clinical treatment of hypertension and other cardiovascular and cerebrovascular dis- eases. In this review the stereoselective pharmacodynamics of calciumchannel blockers and chiral drugs are summarized.
出处
《现代生物医学进展》
CAS
2009年第1期181-185,共5页
Progress in Modern Biomedicine
关键词
手性
手性药物
钙通道阻滞剂
立体选择性
chirality
chiral drugs
calciumchannelblocker
stereoselective
