炎性关节炎的生物制剂治疗进展

Therapy Development of Biological Agents in Inflammatory Arthritis

炎性关节炎是一组慢性、进展性炎性疾病,能导致关节疼痛和功能障碍,严重影响患者的生活质量。炎性关节炎治疗困难,既往的多种治疗方法存在疗效差,周期长,诱导缓解困难且缓解期短,容易复发,副作用大的问题。近年来生物制剂发展迅速,并广泛应用于炎性关节炎的治疗。生物制剂对许多其他治疗方法无效的病例有良好疗效,且起效迅速,停药后维持缓解期长。其应用标志炎性关节炎的治疗已经进入靶向治疗时代,目前影响其应用的主要问题是可能诱发感染和肿瘤。本文综述了近年研究开发治疗炎性关节炎的生物制剂及其分类、特性和临床应用。

Inflammatory arthritis is a group of chronic, progressive inflammatory condition that can lead to significant disability and severe joint pains, influencing the life quality of patient severely. The treatment of inflammatory arthritis is very difficult. Multiple previous medical treatments have showed poor effectiveness, long period, difficulty to induce remission,being easy to recur, and severe side effects. Recently, biological agents developed rapidly. They have been widely used in the treatment of inflammatory arthritis. Biological agents have a good curative effect on the cases.They appear rapidly and have abiding effect. The use of biological agents is a symbol of the era of targeted therapy. Currently, the majorside effects of biological agents are inducing infection and tumors. Here we have reviewed the recent research progress about biological agents in treating inflammatory arthritis from its classification, peculiarity and clinical application.