血管性痴呆与血浆同型半胱氨酸水平关系的研究

Relationship between vascular dementia and homocysteine

目的探讨血管性痴呆（VD）与血浆同型半胱氨酸（Hcy）水平的关系。方法将研究对象分为VD组（50例），非痴呆脑梗死组（50例）和同龄对照组（48例），采用酶联免疫吸附法（ELISA）测定三组患者的Hcy水平，并进行比较。结果VD患者血浆Hcy水平显著高于同龄对照组（P〈0．01）和非痴呆脑梗死组（P〈0．05）。结论高同型半胱氨酸血症是血管性痴呆发病的一个新的危险因素。

Objective To approach the relationship between vascular dementia（VD） and homocysteine（Hcy） level. Methods One hundred and forty - eight cases were divided into three groups ： 50 VD cases, 50 cerebral infarction cases and 48 normal cases. Applying ELISA to investigate the level of Hcy and comparing the Hcy level among those three groups. Results The Hcy level of VD group was higher than cerebral infarction group （ P 〈 0.01 ） and higher than normal group （ P 〈 0.05 ）. Conclusions Homocysteine - emia is a new risky factor of VD.