胸液中腺苷脱氨酶活性水平对胸液的鉴别诊断价值

Clinical investigation of ADA in diagnosis and differential diagnosis of tuberculosis and cancerous in pleural effusion

目的通过检测胸液中腺苷脱氨酶（ADA）活性水平，探讨其对诊断结核性胸膜炎及癌性胸液患者的临床意义。方法对237例结核性胸膜炎72239例癌性胸液进行ADA活性检测。结果结核性胸膜炎患者胸液中ADA活性为（56±18）U／L，癌性胸液（16±8）U／L，前者明显高于后者（P〈0．01）。结核性胸膜炎组经有效抗结核治疗后胸液中ADA活性明显下降，而癌性胸液化疗后胸液中ADA活性下降不明显。结论检测胸液ADA活性对鉴别胸液的良、恶性有较大的帮助。可作为结核性胸膜炎的诊断和鉴别诊断以及疗效观察指标，具有重要的临床实用价值。

Objective To investigate the value of ADA in the diagnosis and distinguish diagnosis in tuberculoses and cancerous pleural effusion. Methods ADA activities were examined in 237 tuberculoses pleurisy and 239 cancerous pleural effusion patients. Results ADA activity was （56±18 ） U/L in the tuberculoses effusion patients, while （16 ± 8） U/L in the cancerous ones. The difference between them had statistically significance （ P 〈 0.01 ）. ADA activity decreased obviously in the tuberculoses pleurisy patients after treatment, while not in tad cancerous ones. Conclusions ADA examination is very helpful in the distinguish diagnosis of tuberculoses and cancerous pleural effusion.