摘要
目的探讨脂蛋白相关磷脂酶A2基因R92H和A379V多态性位点与冠心病遗传易感性的关系。方法采用单荧光标记探针技术检测261例冠心病患者、263例正常对照者脂蛋白相关磷脂酶A2基因R92H和A379V基因型。结果(1)92H等位基因携带者患冠心病的风险是92R等位基因携带者的1.75倍(P〈0.01);(2)冠心病组中单倍型379A92H的频率分布显着高于对照组(P〈0.01);(3)Logistic回归分析提示,R92H位点等位基因92H是冠心病的独立危险因素。结论脂蛋白相关磷脂酶A2基因R92H多态性与汉族人冠心病遗传易感性独立相关。
Objectives To investigate the association between R92H and A379V point mutation of lipoprotein-associated phospholipaseA2 (Lp-PLA2) and the patients with coronary heart disease, Methods 261 CHD patients and 263 normal controls were genotyped by using single-labeled probe technique. Results Compared with RR genotype, the relative risk for CHD in people with RH genotypes was 1.77 ( P 〈0.01 ). The relative risk for CHD in people with 92R allele was 1.75 higher than 92H allele (P 〈 0.01 ). The two polyn, orphisms of the LP-PLA2 gene were in strong linkage disequilibrium (LD). The frequency of the haplotype 379A92H was significantly (P 〈 0.01 ) higher in CHD patients than normal controls. When allied-gene analysis was performed for RR and AV genotype ,the risk of coronary heart disease was markedly reduced 46% (0R = 0.54), Binamy logistic regression analysis showed that polymorphism of R92H was an independent risk factor for CHD. Conclusion The polymorphism of R92H of Lp-PLA2 gene could be associated with risk of CHD in Han Chinese.
出处
《临床内科杂志》
CAS
2009年第1期18-20,共3页
Journal of Clinical Internal Medicine
基金
江苏省常州市卫生局重大招标项目(ZD200709)
关键词
脂蛋白相关磷脂酶A2
基因
多态性
冠心病
Lipoprotein-associated Phospholipase A2
Gene
Polymorphism
Coronary Heart Disease