进展性前列腺癌中Fas和Survivin的表达及其相关性研究

Study on expressions and correlation of Fas and Survivin in progressive prostate cancer

目的:通过检测凋亡相关蛋白Fas、Survivin在进展性前列腺癌(PCa)中的表达及两者的相关性,探讨前列腺癌的发生、发展机制,指导进展性前列腺癌的治疗。方法:应用免疫组化染色(SP)法,检测Fas、Sur-vivin在59例前列腺癌及35例良性前列腺增生(BPH)组织中的表达情况。结果:59例前列腺癌标本中,Fas、Survivin阳性表达率分别是45.8%(27/59)、44.1%(26/59);35例BPH标本中,Fas、Survivin阳性表达率分别是68.6%(24/35)、22.9%(8/35),前列腺癌与BPH组间差异均有显著性意义(P<0.05)。前列腺癌中Sur-vivin表达与病理分级密切相关(P<0.05)。前列腺癌中Fas与Survivin表达呈正相关(r=0.302,P<0.05)。结论:Fas和Survivin在进展性前列腺癌中发生异常表达;联合检测Fas和Survivin蛋白,有助于对进展性前列腺癌细胞的侵袭力作出正确评价,以指导临床治疗。

Objective：By means of detecting the expressions of Fas, Survivin and their correlation in Progressive prostate cancer （PCa） ,we want to investigate the mechanism of development and progression of PCa, and further to guide the endocrine therapy. Methods： Fas, Survivin expressions were assayed in 59 cases of PCa and 35 cases of be- nign prostatic hyperplasia （BPH） by means of immunohistochemistry （SP）. Results：The expression of Fas was de- tected in 27 of the 59 cases of progressive PCa and 24 of 35 cases of BPH, and that of Survivin in 26 of the 59 PCa and 8 of the 35 BPH patients. Fas expression was significantly higher in BPH than in cancer tissues （P 〈 0.05 ）, and Survivin expression was significantly higher in cancer tissues than in BPH （P 〈 O. 05）. The Survivin expression was strongly associated with pathological grades in PCa （ P 〈 0.05 ）. A significant correlation was observed between Fas and Survivin expression in PCa（ r =0.302,P 〈 0.05）. Conclusion-There is abnormal expression of Fas and Survivin in progressive PCa. The detection of Fas and Survivin protein in PCa may help to evaluate the degree of cell apoptosis and decide the therapeutic strategies.