摘要
埃兹蛋白(Ezrin)是连接细胞膜和细胞骨架之间的膜细胞骨架连接蛋白,由于Ezrin细胞中的特殊位置,不仅在细胞的运动、黏附和信号转导等正常生理活动中起重要作用,其在肿瘤细胞转移过程中的作用也逐渐受到重视。
出处
《现代肿瘤医学》
CAS
2009年第1期171-173,共3页
Journal of Modern Oncology
参考文献17
-
1Martin TA, Harrison G, Mansel RE, et al. The role of the CD44/ ezrin complex in cancer metastasis [ J ]. Crit Rev Oncol Hematol, 2003, 46(2) :165 - 186.
-
2Polesello C, Payre F. Small is beautiful: what flies tell us about ERM protein function in development[ J]. Trends Cell Biol,2004, 14(6) :294 -302.
-
3Bretscher A, Edwards K, Fehon RG. ERM proteins and merlin: integrators at the cell cortex[J]. Nat Rev Mol Cell Biol, 2002, 3 ( 8 ) : 586 - 599.
-
4Pujuguet P, Del Maestrol, Gautreau A, et al. Ezrin regulates E - cadherin - dependent adherens junction assembly through Racl activation[J]. Mol Biol Cell,2003,14 (5) : 2181 -2191.
-
5Fievet BT, Gautreau A, Roy C, et al. Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin[J]. J Cell Biol, 2004, 164(5) : 653 -659.
-
6Crepaldi T, Gautreau A, Comoglio PM, et al. Ezrin is an effector of hepatocyte growth factor - mediated migration and morphogrnesis in epithelial cells[J]. J Cell Biol, 1997, 138(2) :423 -434.
-
7Ng T, Parsons M, Hughes WE, et al. Ezrin is a downstream effec- tor of trafficking PKC - integrin complexes involved in the control of cell motility[J]. EMBO J, 2001,20(11) : 2723 - 2741.
-
8Stapleton G, Malliri A, Ozanne BW. Downregulated AP - 1 activi- ty is associated with inhibition of Protein - Kinase - C - dependem CD44 and ezrin localisation and upregulation of PKC theta in A431 cells[J]. J Cell Sci, 2002, 115(13) : 2713 -2724.
-
9Xu Y, Yu Q. E - cadherin negatively regulates CD44 - hyaluronan interaction and CD44 - mediated tumor invasion and branching morphogenesis[J]. J Biol Chem,2003,278 (10) :8661 - 8668.
-
10Yu Y, Khan J, Khanna C, et al. Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six - 1 as key metastatic regulators [ J ]. Nat Med,2004,10 (2) :175-181.
同被引文献18
-
1王红建,史成章,秦先锋,黄秋实.Ezrin、FAK及E-cadherin在大肠癌组织中的表达及其临床意义[J].世界华人消化杂志,2007,15(6):591-595. 被引量:9
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2Nebil Bal,Sedat Yildirim,Tarik Z Nursal,Filiz Bolat,Fazilet Kayaseluk.Association of ezrin expression in intestinal and diffuse gastric carcinoma with clinicopathological parameters and tumor type[J].World Journal of Gastroenterology,2007,13(27):3726-3729. 被引量:9
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3Liu XY,Yang JL,Chen LJ,et al. Comparative proteomics and correla- ted signaling network of rat hippocampus in the pilocarpine model of temporal lobe epilepsy[ J ]. Proteomics ,2008,8 ( 3 ) :582 - 603.
-
4Sutula TP, Pitkanen A. More evidence for seizure-induced neuron loss:is hippocampal sclerosis both cause and effect of epilepsy [ J ]. Neurology ,2001,57(2) : 169 - 170.
-
5Yang JW, Czech T, Felizardo M, et al. Aberrant expression of cytoskel- eton proteins in hippocampus from patients with mesial temporal lobe epilepsy[ J]. Amino Acids,2006,30(4) :477 -493.
-
6Greene ND, Bamidele A, Choy M, et al. Proteome changes associatedwith hippocampal MRI abnormalities in the lithium pilocarpine-in- duced model of convulsive status epilepticus [ J]. Proteomies,2007,7 (8) :1336 -1344.
-
7]Binder DK,Steinhauser C. Functional changes in astroglial cells in ep- ilepsy[ J ]. Glia ,2006,54 ( 5 ) :358 - 368.
-
8Xu Z,Xue T,Zhang Z, et al. Role of signal transducer and activator of transcription-3 in up-regulation of GFAP after epilepsy[ J ]. Neuro- chem Res,2011,36(12) :2208 -2215.
-
9林卫红,孟红梅,王赞,马涤辉,杨立彬,崔俐,张淑琴.杏仁核点燃大鼠海马区损伤与胶质纤维酸性蛋白的表达[J].吉林大学学报(医学版),2007,33(5):837-840. 被引量:1
-
10张肖肖,辛彦.Ezrin蛋白与肿瘤转移关系的研究进展[J].中国肿瘤临床,2007,34(23):1377-1380. 被引量:7
引证文献2
-
1周敏仪,祁岩超,罗超权.Ezrin及其与恶性肿瘤关系的研究进展[J].临床医学工程,2010,17(5):154-156. 被引量:1
-
2尹小花,郭世杰,解文菁,常明,孟红梅.海人酸颞叶癫痫大鼠海马组织中细胞骨架蛋白的差异表达[J].中风与神经疾病杂志,2013,30(4):355-358.
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1杜丽敏,王如美,时志民,沈利军,李文静,王蕾.膜细胞骨架连接蛋白Ezrin在乳腺癌转移的表达及意义研究[J].实用心脑肺血管病杂志,2011,19(10):1665-1667. 被引量:2
-
2郑国荣,程翌,熊毅敏,高娟,徐维田,许桦林.骨桥蛋白、CD44v6、膜细胞骨架连接蛋白在胃癌组织中的表达及意义[J].华南国防医学杂志,2009,23(6):4-6. 被引量:3
-
3贾葆青,贾向东,杨勇,李军华,成绥生,巴特尔.贲门癌417例外科治疗体会[J].内蒙古医学院学报,2008,30(1):52-53.
-
4程翌,徐维田,熊毅敏,黄海涛,高娟,郑国荣.膜细胞骨架连接蛋白(Ezrin)和bcl-2在胃癌中的表达及临床意义[J].医药论坛杂志,2011,32(12):22-24. 被引量:1
-
5郭艳峰,王如美,邵海琴,高建洲,聂栓锁,董超颖.膜细胞骨架连接蛋白及基质金属蛋白酶-2在乳腺癌组织中的表达及其临床意义[J].河北医科大学学报,2012,33(7):829-831. 被引量:1
-
6顾敏,党胜春.肝癌中膜细胞骨架连接蛋白的表达及意义[J].临床医学工程,2009,16(3):64-65.
-
7兰岚,孙铁英,刘东戈,庞建欣,杨丽,杨纯正,熊冬生.Ezrin在肺癌中的表达及临床意义[J].中国肺癌杂志,2008,11(1):67-73. 被引量:8
-
8吴旭.十二指肠少见病3例误诊分析[J].华北煤炭医学院学报,2001,3(1):60-60.
-
9李向东.超选择肝动脉栓塞治疗肝海绵状血管瘤效果观察[J].中国煤炭工业医学杂志,2009,12(3):414-415.
-
10贺华勇,朱小勇,乔士兴.膜细胞骨架连接蛋白和α-连接蛋白在胃癌组织中的表达及临床意义[J].现代医院,2015,15(12):29-31. 被引量:2