恶性黑素瘤和皮肤色素减退

Malignant melanoma and cutaneous depigmentation

恶性黑素瘤可伴有多种皮肤色素减退的表现，其发病率高于普通人群，伴发者的预后相对较好。机制可能是对同时存在于正常黑素细胞和黑素瘤细胞上的黑素共同抗原免疫反应的结果，或是一种抗肿瘤药物样反应。色素痣周围或远处突然出现白癜风样皮损、晕痣等皮肤色素减退，有助于普通人群早期发现恶性黑素瘤和已患有恶性黑素瘤者早期发现转移。

Many kinds of cutaneous hypopigmentation may appear in patients with malignant melanoma, with a relatively higher incidence compared with general population. The appearance of hypopigmentation may predict a better prognosis of malignant melanoma. This depigmentation could be either a consequence of dualistic immune-mediated response against common antigens shared by normal melanocytes and malignant melanoma cells, or a kind of antineoplastic-like reaction. The sudden emergence of vitiligo-like hypopigmentation or halo nevi near or apart from preexisting melanocytic nevi or malignant melanoma, may benefit the early diagnosis of malignant melanoma and its metastasis.