细胞因子在白癜风发病机制中的作用

Roles of cytokines in the pathogenesis of vitiligo

白癜风由于表皮黑素细胞的功能丧失而引起。细胞因子通过自分泌或旁分泌的方式影响黑素细胞的生物学特性。多种细胞因子及黑素细胞表面存在的细胞因子受体在黑素细胞的生长、分化、增殖、凋亡及其黑素产生及转运过程中起重要作用。促黑素细胞激素、粒细胞-巨噬细胞集落刺激因子、干细胞因子、碱性成纤维细胞生长因子等促进黑素细胞的生长、分化、增殖，肿瘤坏死因子-α、白介素等抑制黑素细胞生长。

Vitiligo is associated with the function loss of epidermal melanocytes. Cytokines can affect the biological characters of melanocytes through autocrine or paracrine modes of action. Several kinds of cytokines and their receptors on melanocytes play important roles in the growth, differentiation, proliferation, apoptosis, production and transport of melanin, of melanocytes. It has been demonstrated that the growth, differentiation and proliferation of melanocytes can be promoted by melanocyte-stimulating hormone, granulocyte-macrophage colony stimulating factor, stem cell factor, basic fibroblast growth factor, etc, whereas tumor necrosis factor α and interleukin have an inhibitory effect on the growth of melanocytes.