摘要
目的:探讨电针对脑梗死患者血清中谷胱甘肽过氧化物酶(GSH-Px)活性及谷胱甘肽(GSH)含量的影响。方法:利用比色法对20例正常人及20例急性脑梗死患者电针治疗前、后血清中GSH含量与GSH-Px活性分别进行测定,并对比分析。结果:急性脑梗死患者电针治疗后血清中GSH含量(11.95±1.67)mg/L、GSH-Px活性(192.49±19.27)IU比治疗前[(2.53±0.84)mg/L,(122.40±24.26)IU]和正常组[(4.98±0.83)mg/L,(144.06±35.07)IU]都显著性增高(P<0.01);电针前与正常组比较,GSH含量、GSH-PX的活性有显著性减低(P<0.01)。结论:电针治疗能提高人体血清中抗氧化剂的含量,对脑梗死患者因氧化应激生成的自由基有一定的清除效应。
Objective: To investigate the effects of electroacupuncture (EA) on activity of GSH-Px and serum contents of GSH in patients with cerebral infarction. Methods: Serum levels of GSH-Px and GSH in 20 patients with cerebral ischemia and 20 healthy controls were determined by colorimetry and compared between the two groups. Results: After treatment with electroacupuncture, the serum levels of GSH (11.95±1.67)mg/L and GSH-Px activity (192.49±19.27)IU in the ischemic patients were significantly increased as compared with baseline [(2.53±0.84)mg/L and (122.40±24.26)IU, P〈0.01 ] and with the control group [(4.98±0.83)mg/L and (144.06±35.07)IU, P〈0.01 ]. But GSH-Px activity and GSH content in serum in the pre-EA patients were found to be much lower than those in the control group (P〈0.01). Conclusion: EA was shown to increase the activities of anti-oxidants in human, which may be useful to scavenge free radicals generated from oxidative stress in patients with cerebral infarction.
出处
《广州医学院学报》
2008年第4期17-19,共3页
Academic Journal of Guangzhou Medical College
基金
广州巿科技计划项目(2007J1-C0051)
关键词
脑梗死
谷胱甘肽
谷胱甘肽过氧化物酶
电针
自由基
脑缺血再灌注
脂质过氧化
氧化应激
cerebral infarction
glutathione
glutathione peroxidase
electroacupuncture (EA)
free radical
cerebral ischenmia-reperfusion
lipid peroxidation
oxidative stress