营养治疗对溃疡性结肠炎肠道免疫屏障的疗效

The effect of nutritional treatment on intestinal immunological barrier in ulcerative colitis

溃疡性结肠炎(UC)是原因不明的非特异性结肠炎症性疾病,目前认为肠道免疫功能失调是溃疡性结肠炎发病的根本原因,针对肠道免疫功能失调的治疗是目前溃疡性结肠炎治疗研究的热点。由于药物的不良反应和使用的限制,溃疡性结肠炎的临床治疗有效率仅50%左右,并且还无有效控制复发的治疗手段。近期溃疡性结肠炎的研究发现不同形式的营养治疗不仅能够改善患者的营养状态,有些营养成分还具有调整炎症反应、改善肠道免疫屏障功能的作用。

Ulcerative colitis （UC） is a kind of non-specificintestinal disease with unknown etiology. Immunologic dysfunction of intestinal tract is considered as fundamental etiology of ulcerative colitis. Treatment aimed at immunologic dysfunction of intestinal tract becomes a hot issue in therapeutic studies of ulcerative colitis. Therapeutic efficiency of ul- cerative colitis is only about 50% with few ways to prevent relapse because of adverse events and limitations of medi- cines. Recently, studies on ulcerative colitis indicate that different formulations of nutritional treatment improve nutri- tional status of patients. Furthermore, some nutrients can regulate inflammation and improve the function of intestinal immunological barrier.