纽蛋白在胃上皮内瘤变的表达及临床意义

Expression of Vinculin in Stomach Intraepithelial Neoplasia and Clinical Significance

目的探讨纽蛋白(vinculin)在胃上皮内瘤变的表达及对胃癌预后的影响。方法应用免疫组织化学技术S-P法,检测20例正常胃黏膜、20例胃黏膜慢性炎、10例萎缩性胃炎、12例胃黏膜上皮内肿瘤、50例胃腺癌中纽蛋白的表达,利用SAS9.0对数据进行分析。结果纽蛋白细胞骨架蛋白在正常胃黏膜高表达,随着病变加重而表达减弱。在胃癌中显著低于上皮内瘤变(P<0.05)且与胃腺癌的浸润深度、淋巴结转移、TNM分期及生存期等胃癌生物学行为有关。结论纽蛋白细胞骨架蛋白在胃上皮内瘤变过程中起作用,纽蛋白的失表达对胃癌的预后有重要的临床意义。

Objective To study the expression of vinculin in gastric carcinoma and stomach intraepithelial neoplasia and its clinical significance. Methods The expression of vinculin proteins in carcinoma and stomach intraepithelial neoplasia was examined by immuno- histochemical staining. The data was analyzed by SASg. 0 statistical software. Results The higher expression of vinculin appeared in nomal gastric mucosa. With the lesion progressing, the expression was decreased. The expression in gastric carcinoma was remarkably lower than that in stomach intraepithelial neoplasia （P 〈 0.05 ） and was related to invasion,lymphatic metastasis, staging of TNM and survival date of the biological behaviour of gastric carcinoma. Conclusion Vinculin play an important role in stomach intraepithelial. Missing expression of vinculin protein has important clinical significance on the prognosis of stomach cancer.