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Survivin的表达和微血管密度在胸腺肿瘤中的意义 被引量：2

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摘要 目的:探讨survivin、微血管密度(microvessel density,MVD)在胸腺肿瘤中的表达意义和关系。方法:采用免疫组织化学方法,检测16例胸腺增生、22例非侵袭性胸腺瘤、25例侵袭性胸腺瘤、9例胸腺癌中survivin、MVD的表达。结果:在4组胸腺肿瘤中survivin的阳性率分别为18.7%(3/16)、50.0%(11/22)、84.0%(21/25)、88.9%(8/9),MVD的值分别为2.8125±2.19754、6.1818±3.83761、10.4400±4.70886、33.2222±9.44428。survivin的阳性率和MVD值与Masaoka分期有关(P<0.05),与是否合并重症肌无力无关(P>0.05。随着survivin表达程度增强,MVD值表达增高(P<0.05)。结论:Survivin和MVD在胸腺肿瘤的侵袭性中起重要作用,联合检测两者将有助胸腺瘤侵袭性的分析判断,有利于临床进一步治疗。
作者 管伟 黄杰 范国华 林慧庆
机构地区 武汉大学人民医院胸外科 浙江省义乌市中心医院胸心外科
出处 《实用医学杂志》 CAS 北大核心 2009年第1期74-75,共2页 The Journal of Practical Medicine
关键词 胸腺肿瘤 免疫组织化学 血管密度 SURVIVIN 微血管密度
分类号 R736.3 [医药卫生—肿瘤]
  • 相关文献

参考文献11

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共引文献3

同被引文献19

  • 1王玲,董昌元,张文君,易建华,姚启盛,王贤明.彩色多普勒检测前列腺癌血流及其与微血管密度的关系[J].郧阳医学院学报,2005,24(1):9-11. 被引量：3
  • 2周琦,黄林.子宫内膜癌组织中survivin蛋白和CD34表达的意义及相关性的初步研究[J].临床肿瘤学杂志,2006,11(1):15-18. 被引量：4
  • 3席银雪,宋鑫,陈惠新,彭挺生,陈旻湖.微血管密度在胃癌癌变多阶段组织中的表达及其意义[J].中华医学杂志,2006,86(48):3405-3408. 被引量：14
  • 4曹希亮,高江平,许承斌,唐杰,文载律,洪宝发.前列腺穿刺病理组织学类型在不同PSA水平中的分布[J].临床泌尿外科杂志,2007,22(2):109-110. 被引量：10
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实用医学杂志
2009年 第1期

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