活血三步法对卵巢过度刺激征的防治及对妊娠结局的影响

Three-Step Method of Promotion of Blood Circulation in the Prevention of Ovarian Hyperstimulation Syndrome and the Impact on the Result of Pregnancy

目的：探讨“活血三步法”对卵巢过度刺激征（OHSS）的防治及对妊娠结局的影响。方法：对70例因多囊卵巢综合征、年轻、瘦小、有高敏感性的不孕症应用促排卵后每侧卵巢有3—5个Ф为16mm以上卵泡生长的患者，分为治疗组与对照组。治疗组采用“活血三步法”。并采用血府逐瘀汤做对照。结果：治疗组与对照组卵泡破裂数、周期取消率、临床妊娠率，对比差别均有统计学意义（P〈0．05）。与对照组对比，轻度OHSS发生率有增高趋势，但轻、中、重度OHSS发生率、流产率，多胎妊娠率、减胎率，孕12周胎儿存活率，对比差别均无统计学意义（P〉0．05）。结论：“活血三步法”能有效减少中、重度OHSS的发生，提高临床妊娠率，不增加流产率及多胎妊娠率，对于促排卵中高反应病人是避免周期取消的一个艮好选择。

Objective：To explore the three-step method of promotion of blood circulation in the prevention of ovarian hyperstimulation syndrome（OHSS） and the impact on the result of pregnancy. Methods：After useing the medicine of promoting ovulation to 70 cases of sterility patients who were due to polycystic ovarian syndrome （PCOS）, young, weak, and a high sensitivity, some patients who had 3 -5 follicles （Ф ≥ 16mm）in each ovary, were divided into the treatment group and the control group. The threestep method of promotion of blood circulation was used in the treatment group, nevertheless ＂Decoction for Removing Blood Stasis in the Chest＂ was used in the control group. Results：The differences of the follicle rupture rate, cycle cancellation rate, clinical pregnancy rate between the treatment group and the control group all had statistical significance. Compared with the control group, there was a increased trend in the incidence of slight OHSS. However, the differences of the incidence of slight, moderate and severe OHSS, the abortion rate, the multiple pregnancy rate, fetal reduction rate, the rate of fetal who survived above 12 weeks between the treatment group and the control group, were no statistical significance（ P 〉 0. 05 ）. Conclusion ：The results show that invigoration of the kindney to promote blood circulation method can effectively reduce the incidence of moderate, and severe OHSS,and improve clinical pregnancy rate. But it doesnl increase the abortion rate and the multiple pregnancy rate. So it is a good choice to avoid cycle cancellation for high-response patients in promote ovulation process.