高强度聚焦超声对人及实验动物各系统器官的生物学效应

Biological effect of high intensity focused ultrasound on organs of human and experimental animals

高强度聚焦超声辐照人及实验动物各系统器官后各系统器官的病理变化主要经历急性期、亚急性期和慢性期3个时期,其病理特点可概括为组织的充血、水肿、凝固性坏死;组织增生、修复、成纤维细胞浸润;瘢痕组织形成。文章通过阐述高强度聚焦超声生物效应机制、高强度聚焦超声对人及实验动物各系统器官的生物学效应两方面的内容,得出结论:高强度聚焦超声技术能够靶向损伤人或实验动物各组织器官,产生特定的生物学效应,其在各种良、恶性肿瘤、慢性疼痛等疾病的治疗具有很大的潜在价值。

The pathological changes of high intensity focused ultrasound （HIFU） for organ ablation involve three periods： acute stage, subacute stage and chronic phase. The pathological characteristics include hyperemia, edema, and coagulative necrosis of tissues, tissue proliferation, recovery, the infiltration of fibroblast and formation of scar tissue. This paper introduced the bioactive mechanism of HIFU, effects of HIFU on human and animals, indicating H1FU technique can damage target organs and tissues of human and experimental animals, which has specific biological effect. And it has great potentials to treat benign and malignant tumor and chronic pain.