摘要
1-甲基吲唑-3-羧酸于氯化亚砜中制成酰氯的甲苯溶液,滴加至含有三乙胺的endo-9-甲基-9-氮杂二环[3.3.1]壬-3-胺中反应,成盐酸盐后得盐酸格拉司琼,收率为92%。
1-Methylindazole-3-carboxylic acid was treated with SOC12 to form its acyl chloride and reacted with endo-9-methyl-9-azabicyclo [3.3.1] non-3-ylamine in the presence of Et3N, followed by treatment with HCl to give granisetron hydrochloride in 92 % yield.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2009年第1期12-13,共2页
Chinese Journal of Pharmaceuticals
