穿琥宁注射液的急性毒性试验

Study on Acute Toxicity of Potassium Dehydroandrograpolide Succinate Injection in Mice

通过腹腔注射法对小鼠给药,连续观察7 d,结果表明,穿琥宁注射液对小鼠的半数致死量(LD50)为757 mg/kg,LD50的95%可信限为861.8 mg/kg^701.7 mg/kg,说明穿琥宁注射液毒性小,应用安全。

The mice were given potassium dehydroandrograpolide succinate injection by intraperitoneal injection,and observed for 7 days continuously. Results indicated that the LD50 of potassium dehydroandrograpolide succinate injection in mice was 757 mg/kg,95%confidence limits was 861.8 mg/kg-701.7 mg/kg. All these results confirmed that no acute toxcity was found in potassium dehydroandrograpolide suecinate injection.