黄芩茎叶总黄酮治疗2型糖尿病性高脂血症大鼠的实验研究

Experimental Study of Total Flavonoids from Stem-leaf of Scutellaria Baicalensis in Treating Type 2 Diabetic Hyperlipidemia

目的观察黄芩茎叶总黄酮(SSTF)对2型糖尿病性高脂血症大鼠血糖、血脂代谢及胰岛素抵抗的影响,探究其可能的作用机制。方法高脂饮食加小剂量链脲佐菌素(STZ)建立2型糖尿病合并高脂血症大鼠模型,观察SSTF对大鼠血糖、血脂、胰岛素敏感性指数、抗氧化能力等方面的影响。结果SSTF大、小剂量组(150,75mg·kg-1)能显著降低实验大鼠空腹血糖(FBG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平,不同程度的降低甘油三酯(TG)水平,显著升高高密度脂蛋白胆固醇(HDL-C)水平和胰岛素敏感性指数(ISI)。SSTF能显著降低血清和肝脏中丙二醛(MDA)的含量,显著增加血清超氧化物歧化酶(SOD)的活性,不同程度地提高血清谷胱甘肽(GSH)含量。结论黄芩茎叶总黄酮降糖、降脂作用确切,并能改善胰岛素抵抗作用。SSTF的作用机制可能和其显著的抗氧化作用有关。

Objective To investigate the effect of Scutellaria baicalensis stem - leaf total flavonoids （SSTF） on blood glucose, blood lipid levels and insulin resistance in type 2 diabetic rats with hyperlipidemia, and to explore the possible therapeutic mechanism. Methods Experimental rat model was established by feeding high -fat diet and intraperitoneal injection of small - dose streptozotocin. The effects of SSTF on blood glucose, blood lipid, insulin sensitive index （ISI） and antioxidative capacity of experimental rat model were investigated. Results SSTF significantly reduced the serum fasting blood glucose （FBG）, total cholesterol （TC）, and low- density lipoprotein cholesterol （LDL-C） levels, increased high -density lipoprotein cholesterol （HDL -C） level and ISI, and reduced triglyceride （TG） level to some extent. SSTF also had an effect on decreasing malondialdehyde （MDA） content in both serum and liver tissue, increasing serum superoxide dismutase （SOD） activity significantly and glutathione （GSH） content to some extent. Conclusion SSTF have significant effect on decreasing blood glucose and blood lipid and improving insulin resistance in type 2 diabetic rats with byperlipidemia. Its therapeutic mechanism may be related to the antioxidation function.