利凡诺与米非司酮联合用于中期妊娠引产临床观察

Clinical observation of rivanol combined with mifepristone for the termination of mid-trimester of pregnancy

目的:观察利凡诺羊膜腔内注射联合米非司酮终止中期妊娠的效果。方法:选择孕16～27周自愿终止妊娠,并行利凡诺引产的健康孕妇200例。随机分在两组,观察组用利凡诺羊膜腔内注射联合米非司酮口服终止妊娠,对照组单纯利凡诺羊膜腔内注射终止妊娠。观察两组宫缩发动时间、宫缩至引产结束时间、引产总时间、出血量、胎盘胎膜残留量。结果:观察组引产总时间短、产后出血少,胎盘胎膜残留量少,与对照组相比,差异有显著性(P<0.05)。结论:利凡诺羊膜腔内注射联合米非司酮口服终止中期妊娠是一种简单、安全、有效、快速的终止妊娠的方法。

Objective ：To observe the labor-inducing effect of combined use of mifepristone and rivanol amnioeentesis in mid-pregnancy.Methods：200 pregnant women of 16-27 weeks indicated for induced labor were studied.The subjeets were divided into 2 groups, experimental group and control group.The women in experimental group were orally given mifepristone combined amnioeentesis injection of rivanol;while in control group,women were simply treated by amniocentesis injection of rivanol. Two groups were compared with each other on launch time of uterine contraction ,duration from uterine contraction occurrence to abortion accomplishment ,total duration of abortion ,bleeding quantity and placenta membranes residual quantity and complication.Results：Total duration of abortion in experimental group was shorter than that in control group,bleeding quantity and placenta membranes residual quantity in experimental group were less than those in control group,the result was significantly different（P〈0.05）.Conclusion：Mifepristone combined amniocentesis injection of rivanol is an effective, safe, simple and quick method.