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急性巨核细胞白血病细胞遗传学及分子机制研究进展 被引量：4

Research advances on cytogenetic and molecule mechanism of acute megakaryoblastic leukemia
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摘要 急性巨核细胞白血病（AMKL）是一种罕见的血液系统恶性肿瘤，其发病机制尚不明确，目前已发现AMKL存在诸多细胞遗传学改变；GATA1、p53、RUNX1等基因异常在AMKL发病过程中起重要作用，现就AMKL细胞遗传学及分子机制的研究现状作一总结。 Acute megakaryoblastic leukemia （AML-M7） is a rare neoplastic hematologic disorder, the pathogenesis is not clearly. Recent research has found many cytogenetic changes in this disease; and also some genes mutation, such as GATA1, p53, RUNX1 play very important roles in AMKL. The aim of this article is to review the cytogenetic and molecule mechanism of acute megakaryoblastic leukemia.
作者 王婷 付蓉(综述)
机构地区 天津医科大学总医院血液肿瘤科
出处 《白血病．淋巴瘤》 CAS 2009年第1期51-54,共4页 Journal of Leukemia & Lymphoma
关键词 白血病 巨核细胞 急性 细胞遗传学 分子作用机制 Leukemia, acute, megakaryoblastic Cytogenetics Pathogenesis
分类号 R733.71 [医药卫生—肿瘤] R596.1 [医药卫生—内科学]
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参考文献29

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同被引文献21

  • 1陈新敏,冯文莉.慢性粒细胞白血病急变的机理[J].国外医学（输血及血液学分册）,2005,28(1):21-23. 被引量：4
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  • 3吕晓毅,朱娟,李霞,卢香兰,李艳,何娟,翟明.急性巨核细胞白血病20例临床分析[J].中国肿瘤临床与康复,2005,12(5):405-407. 被引量：8
  • 4雷琦,刘英,唐锁勤.儿童急性巨核细胞白血病[J].中国实验血液学杂志,2007,15(3):528-532. 被引量：6
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白血病．淋巴瘤
2009年 第1期

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