^(153)Sm-EDTMP与中草药联合治疗骨转移癌骨痛的近期临床观察

Treating metastatic carcinoma of bone with integrated herds and Samarium-^(153)Sm-EDTMP

目的利用中草药与153Sm-EDTMP联合治疗骨转移癌,以提高153Sm-EDTMP的疗效和减轻其骨髓抑制的副作用。方法选择经临床和病理确诊为肿瘤的患者54例,随机分为A、B两组进行研究。A组即153Sm-EDTMP治疗组,30例;B组即153Sm-EDTMP+中草药治疗组,24例。153Sm-EDTMP用量为37~74 MBq/kg,中草药选用祛风通络、除湿解毒、益肾补气填精之类。结果A组疼痛缓解和生活质量的改善分别为80%和86.1%,外周血白细胞在用药2周后明显下降(P<0.05),血小板在用药后1个月明显下降(P<0.05);B组疼痛缓解和生活质量的改善分别为91.7%和95.8%,外周血象未见明显改变。结论中草药和153Sm-EDTMP联合治疗骨转移癌具有临床应用价值。

Objective To improve anti - pain efficiency of ^153Sm - EDTMP and reduce its adverse side - effect of marrow suppression,herbs were used to treat metastatic carcinoma of bone with ^153Sm - EDTMP. Methods The patients were classified into two groups, group A：30 patients were treated only with ^153 Sm -EDTMP;group B ：24 patients were treated with ^153 Sm -EDTMP and herds. The administered amount of ^153 Sm - EDTMP was 37 - 74 MBq/kg in groups of patients. The herbs include drugs for expelling wind, promoting blood circulation and restoring flow, removing dampness and detoxicating, tonifying the kidney, replenishing Qi, promoting essence and producing marrow. Results In group A ： the anti - pain effective rate and living improvement rate were respectively 80% and 86.7% ,the white bleed cell count was below baseline value 2 weeks post - treatment（ P 〈 0.05 ） and the platelet count was below baseline 4 weeks post -treatmen （ P 〈 0.05 ）. Ingroup B：the anti -pain effective rate and living improvement rate were respectively 91.7% and 95.8% ,the levels of blood cell counts were not significantly different from the baseline data before treatment （ P 〉 0. 05 ）. Conclusion ^153 Sm - EDTMP in conjunction with herbs being used to treat metastatic carcinoma of bone could be valuable in improving anti - pain efficiency of ^153Sm - EDTMP and reducing it＇s adverse side - effect of marrow suppression.