Livin,Survivin在骨肉瘤中的表达及临床意义

EXPRESSION OF LIVIN AND SURVIVIN IN OSTEOSARCOMA AND ITS CLINICAL SIGNIFICANCE

目的研究Livin，Survivin在骨肉瘤中的表达和相关性及其临床意义。方法用免疫组织化学过氧化物酶标记链霉卵白素法检测31例骨肉瘤组织和5例正常骨组织中Livin，Survivin蛋白的表达情况。结果Livin在骨肉瘤组织中的阳性表达率为61．3％，明显高于正常骨组织0％，但与年龄、性别、肿瘤大小、部位、病理学分型和Enneking外科分期无关。Survivin在骨肉瘤的阳性表达率为58．1％，明显高于正常骨组织的20％。Survivin的表达与Enneking外科分期有关。IAvin和Survivin无明显相关性。结论Livin在骨肉瘤的发生发展过程中起重要作用，有望成为肿瘤治疗的新靶点。

Objective To investigate the expression of Livin and Survivin in osteosarcoma and analyse the correlation between Livin and Survivin in osteoresarcoma. Methods The expression of Livin and Survivin were detected in 31 cases of human osteosarcoma and 5 cases of normal human bone with immunohistochemistry by SP method. Results Livin positive expression rate was 61.3 % in osteosarcoma,which was significantly higher than that of normal bone（0 %）. Livin positive expression was not associated with age, sex, tumor size, tumor location, pathological types and Enneking clinical stages. Survivin positive expression rate was 58.1% in osteosarcoma, which was significantly higher than that of normal bone（20 %）. Survivin positive expression was significantly associated with Enneking clinical stages. There was no correlation between Livin and Survivin in human osteosarcoma. Conclusion Liven could play an important role in tumorigenesis and tumor progression,and it could be a new target for treatment of osteosarcoma.