痰热清联合更昔洛韦治疗手足口病疗效观察

A clinical observation on therapeutic effect of tanreqing combined with ganciclovir for hand-foot-mouth disease

目的探讨痰热清联合更昔洛韦治疗儿童手足口病的临床疗效。方法选取96例手足口病患儿随机分为治疗组和对照组，治疗组应用更昔洛韦和痰热清治疗，对照组采用病毒唑和双黄连治疗。结果观察两组临床症状及体征改善时间，治疗组热退时间、疱疹结痂及消退时间、开始进食时间、痊愈天数均明显短于对照组（平均约2天）（t值分别为20．30、27．20、10．12、17．79、8．84，均P〈0．01），治疗组总有效率亦高于对照组（X2=5．46，P〈0．05），经比较差异具有统计学意义。结论更昔洛韦联合痰热清治疗手足口病疗效确切，值得推广应用。

Objective To observe therapeutic effect of tanreqing combined with ganciclovir for hand-foot-mouth disease. Methods 96 children with hand-foot-mouth disease were divided into treatment group and control group randomly. The children in the treatment group were treated with tangreqing and ganciclovir, while those children in the control group were given virzole and shuanghuanglian for drip. The improvement times of clinical symptoms and signs of children in the two groups were observed. Results The defervescence time, herpes scabbing and regression time, beginning time of food intake and days for cure in the treatment group were all shorter than those in the control group（ t = 20.30, 27.20, 10.15, 17.79 and 8.84 respectively, all P 〈 0. 01 ）. The total effective rate in the treatment group was higher than that in the control group and there was significant diffrence between the two groups （X2 = 5.46, P 〈 0.05 ）. Conclusion The therapeutic effect of tanreqing combined with ganciclovir for hand-foot-mouth disease is significant.