80例宫颈细胞学异常结果分析

An analysis of 80 cases of abnormal cervical cytology

目的分析妇女宫颈上皮内瘤变的高发因素，探讨宫颈癌前病变的预防措施。方法2006年1月-2007年12月对1052例妇女保健门诊宫颈癌筛查患者进行薄层液基细胞学检查，按宫颈表面光滑和糜烂样改变分两组进行对照；按不同年龄分5组进行观察。对80例薄层液基细胞学检查异常者进行阴道镜检查，对阴道镜检查效果满意者在异常阴道镜图像部位进行宫颈活组织检查术，对阴道镜检查效果不满意者进行宫颈管刮术或宫颈锥切术，对活检标本进行病理组织学检查。结果宫颈糜烂样改变组薄层液基细胞学检查异常率明显高于宫颈光滑组，差异有统计学意义（X2=31．60，P〈0．01）；薄层液基细胞学检查异常率20～39岁年龄组明显高于40岁以上年龄组，差异有统计学意义（X2=6．65，P〈0．05）。结论宫颈上皮内瘤变发病年龄趋向年轻化，宫颈糜烂样改变患者为高发人群。

Objective To investigate high risk factor of cervical intraepithelial neoplasia （CIN） and to explore preventive measures of precancerous lesions of uterine cervix. Methods 1 052 women who received cervical carcinoma screening at Maternal Health Clinic of our hospital from Jan. 2006 to Dec. 2007 were examined with thin-Prep cytologic test （TCT） and classified by the bathesda system（TBS）. According to smooth or erosion of the cervix, the women were divided into 2 contrast groups and according to age the women were divided into 5 observation groups. 80 women with abnormal TCT results received colposcopy. Cervical biopsy for those women with satisfactory colposcopy result at site where colposcopy image was abnormal was done and endocervical curettage or conization was performed for those women who had unsatisfactory colposcopy image. Biopsized specimen were sent for pathohistological examination. Results The abnormal rate of TCT in erosion group was higher than the smooth group and the difference was significant （X2 = 31.60, P 〈 0.01 ）. The abnormal rate of TCT in 20 -39 years age group was higher than 40 above years age group and the difference was significant （X2 = 6.65, P 〈 0.05 ）. Conclusion The morbidity age of CIN tends to younger and those women who have cervical erosion are high risk population of CIN.