子宫原发性粘膜相关淋巴组织淋巴瘤病例分析

Clinicopathologic features of primary mucosa-associated lymphoid tissue lymphoma of corpus uteri

目的探讨子宫体原发性粘膜相关淋巴组织淋巴瘤的临床病理特征及免疫表型特点。方法对2例子宫体原发性粘膜相关淋巴组织淋巴瘤患者进行回顾性研究，包括临床病理观察、免疫组化检测等。结果子宫体原发性粘膜相关淋巴组织淋巴瘤临床诊断困难，镜下病理形态多样，可见子宫内膜和／或肌层内淋巴细胞增生，免疫组化B细胞标记（＋）。结论原发性子宫粘膜相关淋巴组织淋巴瘤是一种罕见惰性淋巴瘤，多为偶然发现子宫体占位性病变，临床易漏诊，因此诊断及鉴别诊断要结合临床、病理形态及免疫组化标记等。

Objective To study clinicopathologic and immunohistochemical features of primary mucosa-associated lymphoid tissue（MALT） lymphoma of corpus uteri. Methods The clinicopathologic observations and immunohistochemical detection results of 2 cases of primary MALT lymphoma of corpus uteri were studied retrospectively. Results 2 cases of uterine lymphoma were found incidentally by physical examination. Under microscope,the tumor cells were diversely shaped and lymphocyte hyperplasia in endometrium and/or myometrium were seen. Immunohistochemically, CD20 and CD79a were both positive. Conclusion Primary MALT lymphoma of corpus uteri is a rare indolent lymphoma, most of them are found incidentally as a space occupying lesion. The lymphoma is always misdiagnosed in clinic. So, the diagnosis and differential diagnosis of the tumor should be made by combining clinical manifestations, pathological morphology and immunohistochemical labeling and so on.