血清CHE/ALT比值在肝硬化患者预后及病情判断中的价值

Value of Serum CHE/ALT Ratio in Estimating the Prognosis and Severity of Hepatocirrhosis Patients

目的:探讨肝硬化患者血清CHE/ALT比值的变化及其意义。方法:检测136例健康对照组与973例肝硬化患者的血清CHE/ALT比值,并分析血清CHE/ALT比值变化与肝硬化患者的预后、肝功能损害程度以及某些并发症等的关系。结果:肝硬化患者血清CHE/ALT比值显著低于对照组;肝硬化死亡组血清CHE/ALT比值显著低于存活组;肝硬化肝功能B级组血清CHE/ALT比值显著低于肝功能A级组,肝功能C级组血清CHE/ALT比值显著低于肝功能A级组与B级组;肝硬化并发肝性脑病组血清CHE/ALT比值显著低于未并发肝性脑病组;肝硬化并发原发性肝癌组血清CHE/ALT比值显著低于未并发原发性肝癌组。结论:肝硬化病人血清CHE/ALT比值明显降低,并与肝硬化患者的预后、肝功能损害程度及是否并发肝性脑病及原发性肝癌等因素有密切关系。

Objective： To study the clinical significance of changes of serum CHE/ALT ratio in patients with hepatocirrhosis. Metheds：The serum CHE/ALT ratio in 136 cases from the healthy control group and in 973 cases of hepatoeirrhosis were determined. The relationship between serum CHE/ALT ratio and the factors of prognosis, degree of hypohepatia, some complication etc. in hepatocirrhosis patients was analyzed. Results：The serum CHE/ALT ratio in hepatocirrhosis group was significantly lower than that in control group. The serum CHE/ALT ratio in death, the degree of liver function Child-pugh B, the degree of liver function Chil＆pugh C, complicate hepatic encephalopathy ,complicate primary hepatic carcinoma were significantly lower than that in survival, the degree of liver function Child-pugh A, the degree of liver function Child--pugh A and B , not complicate hepatic eneephalopathy , not complicate, primary hepatic carcinoma groups with hepatocirrhosis,respectively. Conclusion：The serum CHE/ALT ratio was obviously decreased in hepatoeirrhosis patients,and it is closely correlated to the factors of prognosis,degree of hypohepatia, whether complicated hepatic encephalopathy and primary hepatic carcinoma,etc.