缬沙坦联合百令胶囊治疗肾性蛋白尿的疗效观察

Therapeutic evaluation of vaisartan combined with bailing capsule on proteinuria in nephropathy

目的观察缬沙坦联合百令胶囊治疗肾性蛋白尿的疗效。方法筛选60例因各种原因均未做肾活检且尿蛋白在（0．8～3）g／24h的肾病患者，随机分为两组：对照组28例和治疗组32例。两组患者均采用低盐、优质低蛋白饮食，蛋白质摄入量为每天每千克体重0．8g，酌情采用控制感染、利尿、补钙、活性维生素D、控制血压等对症处理措施，并应用缬沙坦160mg／d，在此基础上治疗组加用百令胶囊1．0g，每日3次，观察期为6个月，于治疗前后比较两组患者的蛋白尿水平和肾功能。结果治疗后6个月，对照组、治疗组均取得不同程度的临床疗效，分别为35．71％和56．25％；两组与治疗前比较蛋白尿水平均有显著下降，治疗组比对照组下降更明显（P〈0．05）。结论单用缬沙坦及联合应用缬沙坦和百令胶囊均能降低蛋白尿，但合用百令胶囊疗效更显著。

Objective To investigate the effect of combinative use of valsartan with bailing capsule on proteinuria in nephropathy. Methods The enrollment included 60 cases of chronic kidney disease who haven＇ t been given renal biopsy because of various kinds of reasons and all of their urinary albumin excretion（UAE） were between （0.8 -3.0） g/24 h. These patients were randomly divided into two groups ： control group （ n = 28 ） and treatment group （ n = 32 ） , both of two groups were given valsartan 160 mg/d, and given low salt and low high quality protein diet. we also gave them some relevant treatment, for example, control infection, diuresis, supply calcium, vitamin D, control blood pressure, etc. The treating group were given bailing capsule 3.0 g/d additionally. All the therapies lasted for 6 months ,urinary albumin excretion and renal function were measured before and after the treatment. Results After 6 months,the curative effect of control group was 35.71%, and the treatment group was 56.25% ;Both group＇ s proteinuria were decreased,and the treatment group decreased more obvious. Conclusions Urine protein can be decrease regardless of treating with valsartan only or treating with valsartan combined bailing capsule on kidney disease. And the effect of latter therapy is better than former.