奥硝唑在多壁碳纳米管碳糊电极上的电化学行为及其测定

Electrochemical Behavior of "Ornidazole" at the Multi-wall Carbon Nanotube Paste Electrode and Its Determination

基于对奥硝唑在多壁碳纳米管碳糊电极上的电化学行为及反应机理的研究,提出了测定奥硝唑的电化学分析法,优化了测定奥硝唑的各试验参数。在pH 2.21的B-R缓冲溶液中,奥硝唑浓度在1.0×10-6～5.0×10-4mol·L-1之间与其还原峰电流呈线性关系,检出限为5.0×10-7mol·L-1。用此法测定了片剂中奥硝唑的含量,加标回收率在95%～105%之间,测定值的相对标准偏差(n=7)在5.10%～5.23%之间。试验证实,奥硝唑在电极上的还原反应为主要受扩散控制的不可逆过程。

Based on the results of study on the electrochemical behavior of ＂omidazole＂ （abbreviated as ONZ） at the multi-wall carbon nanotuhe paste electrode and its reaction mechanism, an electrochemical method for determination of ONZ was proposed. Under the optimum experimental condition, in a B-R buffer medium of pH 2. 21, linear relationship between values of reductive peak current and concentration of ONZ in the range of 1.0 × 10^-6 - 5.0 × 10^-4 mol ·L^-1 was obtained, with a detection limit of 5.0 × 10^-7 mol · L^-1. Precision and recovery of the proposed method were tested on the base of samples of ONZ tablets, and values of RSD＇s （n= 7） and of recovery were found in the ranges of 5. 10%- 5. 23% and 95% - 105% respectively. It was shown that the reduction of ONZ is an irreversible process, controlled mainly by diffusion.