分泌性中耳炎辨证分型与血清中PAF含量的相关性研究

Relationship Between Syndrome Differentiation and Serum Platelet Activating Factor Content in Patients with Secretory Otitis Media

目的:探讨血小板活化因子(PAF)在分泌性中耳炎(SOM)发病中的作用及与中医辨证分型的关系。方法:将26例患者辨证分为风热上壅型组13例。痰瘀交阻型13例。采用酶联免疫吸附实验(ELISA法)测定患者血浆中PAF含量,并与14例正常对照组对照。结果:SOM患者血清中的PAF浓度明显高于正常对照组(P<0.01);且风热上壅型组患者血清中PAF含量明显高于痰瘀交阻型组(P<0.05)。结论:PAF与SOM的发病密切相关;血清中的PAF含量对SOM患者微观辨证分型具有一定的参考价值。

Objective:To explore the relationship between syndrome differentiation and serum platelet activating factor (PAF) content in patients with secretory otitis media (SOM).Methods: Twenty-six SOM patients were classified into the syndrome of upward accumulation of wind-heat (n = 13) and the syndrome of stagnation of phlegm and blood-stasls (n = 13).Enzyme-linked immunosorbent assay (ELISA) was used to detect plasma PAF content.The PAF content in SOM patients was compared with that in 14 healthy normal controls.Results:Serum PAF content in SOM patient,was higher than that in the normal control group (P<0.05).and was much higher in the syndrome of upward accumulation of wind-heat (n = 13) than that in the syndrome of stag- nation of phlegm and blood-stasis (P<0.01).Conclusion:PAF involves the pathogenesis of SOM.and serum PAF content exerts some evidence for the microscopic syndrome of SOM patients.