摘要
众所周知,神经激素异常与充血性心力衰竭的病理生理密切相关。改善充血性心力衰竭预后的成功方法主要是阻断神经激素系统的激活。肾素-血管紧张素-醛固酮系统和交感神经系统的拮抗剂和阻断剂显著改善了充血性心力衰竭患者的预后。心力衰竭时过量分泌的精氨酸血管加压素可能加速充血性心力衰竭的病理进程。精氨酸血管加压素受体拮抗剂阻断精氨酸血管加压素的作用,是一种治疗充血性心力衰竭的新方法,可能使患者获益。
Neurohormonal abnormalities contribute to the pathophysiology of congestive heart failure （CHF）. Successful approaches to improving the prognosis of patients with CHF are based largely on therapeutic interruption of activated neurohormonal systems. The use of antagonists and inhibitors of the renin-angiotensin-aldosterone, and sympathetic nervous systems has significantly improved clinical outcomes in CHF. Excessive secretion of arginine vasopressin （AVP） has the potential for deleterious effects on various physiologic processes in CHF. Inhibition of AVP through vasopressin receptor antagonist therapy is a potentially beneficial new therapeutic approach to CHF.
出处
《心血管病学进展》
CAS
2009年第1期95-99,共5页
Advances in Cardiovascular Diseases
