Barrett食管、反流性食管炎与幽门螺杆菌相关性研究

Study on the relationship of Barrett's esophagus and reflux esophagitis with helicobacter pylori

目的:探讨Barrett食管、反流性食管炎与幽门螺杆菌的相关性。方法:胃镜诊断Barrett食管109例,反流性食管炎125例,及对照组70例,分别在其胃窦部大、小弯各取2块活组织行快速尿素酶试验及病理活检检测幽门螺杆菌。结果:Barrett食管幽门螺杆菌感染率为32.31%,反流性食管炎为33.78%,对照组为54.29%。Barrett食管和反流性食管炎分别与对照组比较,差异均有统计学意义(P<0.05)。结论:幽门螺杆菌可能对Barrett食管及反流性食管炎有一定保护作用。

Objective To investigate the relationship of Barrett＇s esophagus and reflux esophagitis with Helicobacter pylori. Methods One hundred and nine patients with Barrett＇s esophagus, 125 patients with reflux esophagitis and 70 normal controls were obtained two pieces of living tissue from greater and lesser curvature of gastric antrum respectively to detect Helicobacter pylori infection by urease test and biopsy. Results The infective rate of Helicobacter pylori was 32. 31% in Barrett＇s esophagus patients, 33. 78% in reflux esophagitis patients and 54. 29% in controls. There was a statistic difference between the two former groups and control group （P〈 0. 05）. Conclusion Helicobacter pylori may have a protective effect on Barrett＇s esophagus and reflux esophagitis.