成骨过程中微小RNAs调控作用的研究进展

DEVELOPMENT OF THE ROLE OF MICRORNAS REGULATION IN OSTEOGENESIS

目的对微小RNAs(microRNAs,miRNAs)在成骨过程中的调控作用及作用机制的研究现状、存在的争议以及研究方向作一综述。方法广泛查阅近年来有关成骨过程中miRNAs的调控作用及作用机制的文献,进行总结与分析。结果miRNAs是近来成骨研究的热点,越来越多资料显示其在骨化过程中发挥重要作用,但确切机制尚未清楚。结论通过应用miRNAs技术促进成骨细胞分化,具有巨大的应用前景,同时将可能获取成骨细胞分化中的miRNAs调控机制,也有利于建立成骨效果比较的研究模型。

Objective To review the progress, controversy and trend in the regulation and mechanism of the microRNAs （miRNAs） during the osteogenesis. Methods Recent literature concerning regulation and mechanism of the miRNAs during the osteogenesis was extensively reviewed, summarized and analyzed. Results Recently miRNAs was a hot topic for osteogenesis. More and more materials showed its important role in ossification, but its definite mechanism was not clear. Conclusion Osteogenesis can be strengthened by miRNAs technology, which has a bright future and may also provide the molecular mechanism. The study on miRNAs of osteogenesis can provide a model to analyze and compare the osteogenetic effects of novel drugs.