摘要
脉络膜新生血管形成的组织病理改变及生化特点与动脉粥样硬化存在着某些相同的特点。氧化型低密度脂蛋白能诱导活性氧簇的生成，引起氧化应激反应，造成细胞毒作用及内皮细胞的损伤，直接或间接促血管生成因子的表达。同时，释放黏附分子和趋化因子并与巨噬细胞相互作用，放大内皮细胞的反应，加重内皮细胞的损伤及功能改变。此外，氧化型低密度脂蛋白影响内皮细胞的增殖及凋亡，并作用于MMPs／TIMPs间平衡进而改变胞外基质。减少动脉粥样硬化的高危因素，针对氧化型低密度脂蛋白的相关治疗有可能成为防治年龄相关性黄斑变性的一种新的有效途径。
出处
《中国实用眼科杂志》
CSCD
北大核心
2009年第1期11-15,共5页
Chinese Journal of Practical Ophthalmology
参考文献29
-
1Catherine A.,Bickol N.,Cara L.,et al.Risk factors for age-related maculopathy.Arch Ophthalmol, 2001 ; 119:1455-1462.
-
2Age-Related Eye Disease Study Research Group.A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss.Arch Ophthalmol,2001,119:1417-1436.
-
3Ephraim Friedman.The role of the atherosclerotic process in the pathogenesis of age-related macular degeneration.Am J Ophthalmol, 2000, 130 : 658-663.
-
4I keda.Paraoxonase gene polymorphisms and plasma oxidized low-density lipoprotein level as possible risk factors for exudative age-related macular degeneration.Am J Ophthalmol, 2001,132: 191 - 195.
-
5Chen M,Narumiya S,Masaki T,Sawamura T.Conserved C-terminal residues within the lectin-like domain of LOX-1 are essential for oxidized low-density lipoprotein binding.J Biol Chem, 2001,355 : 289- 296.
-
6Chen M, Kakutani M, Minami M, et al.Increased expression of lectinlike oxidized low density 1.ipoprotein receptor-I in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.Arterioscler Thromb Vasc Biol, 2000,20:1107-- 1115.
-
7Megumi Honjo, Tatsuya Sawamura, Junichi Hinagata, et al.Expression of LOX-1, an oxidized low-density lipoprotein receptor in choroidal neovascularization.Arch Ophthalmol, 2004,122:1873-1876.
-
8Debra A. ,William G. ;Julia E. ,et al.High-sensitivity c-reactive protein,other markers of inflammation,and the incidence of macular degeneration in women.Arch Ophthalmol, 2007,125 : 300-305.
-
9Veikkola T, Alitalo K.VEGFs receptors and angiogenesis.Cancer Biology, 1999,9 : 211-220.
-
10Ramos,Miguel A.;Kuzuya,Masafumi;Esaki,Teiji,et al.Induction of macrophage VEGF in response to oxidized LDL and VEGF accumulation in human atherosclerotic lesions.Arterioscler Thromb Vasc Biol, 1998,18:1188-1196.
同被引文献37
-
1LaudeA, CackettPD, VithanaEN, et al.Polypoidal choroidal vasculopathy and neovascular age-related macular degeneration:same or different disease?[J]. Prog Retin Eye Res, 2010, 29(1):19-29.DOI:10.1016/j.preteyeres.2009.10.001.
-
2HondaS, MatsumiyaW, NegiA. Polypoidal choroidal vasculopathy:clinical features and genetic predisposition[J]. Ophthalmologica, 2013, 35(6):259-264.DOI:10.1159/000355488.
-
3SuY, ZhangX, ZuoC, et al.Three variants of or near VEGF-A gene are not associated with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in a Han Chinese population[J]. Ophthalmic Genet, 2015, 36(3):218-223.DOI:10.3109/13816810.2013.858753.
-
4NakashizukaH, MitsumataM, OkisakaS, et al.Clinicopathologic findings in polypoidal choroidal vasculopathy[J]. Invest Ophthalmol Vis Sci, 2008, 49(11):4729-4737.DOI:10.1167/iovs.08-2134.
-
5KawamuraA, YuzawaM, MoriR, et al.Indocyanine green angiographic and optical coherence tomographic findings support classification of polypoidal choroidal vasculopathy into two types[J/OL]. Acta Ophthalmol, 2013, 91(6):e474-e481[2015-10-10]. http://onlinelibrary.wiley.com/doi/10.1111/aos.12110.DOI:10.1111/aos.12110.
-
6RishiP, RishiE, MathurG, et al.Ocular perfusion pressure and choroidal thickness in eyes with polypoidal choroidal vasculopathy, wet-age-related macular degeneration, and normals[J]. Eye (Lond), 2013, 27 (9):1038-1043.DOI:10.1038/eye.2013.106.
-
7LeeMY, LeeWK, BaekJ, et al.Photodynamic therapy versus combination therapy in polypoidal choroidal vasculopathy:changes of aqueous vascular endothelial growth factor[J]. Am J Ophthalmol, 2013, 156(2):343-348.DOI:10.1016/j.ajo.2013.04.001.
-
8TongJP, ChanWM, LiuDTet al.Aqueous humor levels of vascuIar endothelial growth factor and pigment epithelium-derived factor in polypoidal choroidal vasculopathy and choroidal neovascularization[J]. Am J Ophthalmol, 2006, 14l(3):456-462.DOI:10.1016/j.ajo.2005.10.012.
-
9KangHM, KohHJ.Two-year outcome after combination therapy for polypoidal choroidal vasculopathy:comparison with photodynamic monotherapy and anti-vascular endothelial growth factor monotherapy[J]. Ophthalmologica, 2014, 231(2):86-93.DOI:10.1159/000354546.
-
10ZengR, WenF, ZhangX, et al.Serum levels of matrix metalloproteinase 2 and matrix metalloproteinase 9 elevated in polypoidal choroidal vasculopathy but not in age-related macular degeneration[J]. Mol Vis, 2013, 19:729-736.
-
1张士胜,廖华萍,张雷,朱彩红,张琼,王玲,王康孙.MMP-9、TIMP-3在小鼠脉络膜新生血管形成中的作用(英文)[J].国际眼科杂志,2008,8(8):1500-1503. 被引量：2
-
2张振海,张永波.基质金属蛋白酶组织抑制剂与动脉粥样硬化[J].中西医结合心脑血管病杂志,2008,6(3):329-330. 被引量：1
-
3FarrukhAli WingC.Chan MikeR.Stevenson K.AlysonMuldrew UshaChakravarthy 许珂.年龄相关性黄斑变性中渗出性病变的血管造影形态学分析[J].美国医学会眼科杂志（中文版）,2005,17(1):58-58.
-
4陈治强,崔恩东,禇化成.中医药治疗渗出性年龄相关性黄斑变性临床观察[J].中国乡村医药,2008,15(6):44-45.
-
5闫焱,王玲.年龄相关性黄斑变性治疗新进展[J].国际眼科杂志,2008,8(5):985-989. 被引量：12
-
6范忠才,彭永权,王艳,罗兴林.慢性心功能不全伴肺部感染患者血清TNF-α和MMPs变化及其临床意义[J].四川医学,2005,26(5):494-496. 被引量：1
-
7张伶俐,周莹,李小荷,李慧,钟明,张薇.中国房颤人群心肌组织中MMPs与TIMPs的mRNA表达水平的Meta分析[J].山东大学学报（医学版）,2015,53(1):47-53. 被引量：3
-
8王伟,胡克.基质金属蛋白酶组织抑制剂与慢性阻塞性肺病[J].咸宁学院学报（医学版）,2010,24(2):178-181.
-
9宋颖,尹路.基质金属蛋白酶组织抑制剂与克罗恩病的研究进展[J].外科理论与实践,2015,20(2):180-182.
-
10章惺惺,蔡雪黎,汪大望.冠心病合并2型糖尿病患者血清MMP-9,TIMP-1及hs-CRP水平的检测及其临床意义[J].温州医学院学报,2009,39(5):439-442. 被引量：4
