梅毒9900例患者流行病学及血清学检测结果分析

Study on Serological Eest and Epidemiology in Syphilis of 9900 Case STD Clinic Patients

目的了解本区域梅毒流行特征和方法学比较。方法对2005～2007年在本院进行梅毒血清学检测的9900例患者资料进行分析,同时评价TRUST,TP-ELISA和TPPA法特异性与敏感性。结果2005～2007年梅毒血清学阳性率分别为2.7%,4.0%,8.7%;3年中一期梅毒分别占55.9%,73.9%和61.3%,二期梅毒分别占33.8%,20.4%和32.1%,三期梅毒相对较少,隐性梅毒分别为8.8%,5.0%和6.0%;TRUST,ELISA和TPPA法敏感性分别为72.0%,87.0%和68.0%,特异性分别为88.0%,95.0%和100%。梅毒患者中男女比例为0.63∶1,初中和小学毕业占62.0%,其他占38.0%,年龄分布主要在青壮年,服务业和打工者占76.0%,其他占24.0%,已婚者占65.0%。结论梅毒血清学试验中敏感性ELISA法较高,特异性TPPA较高。梅毒感染中女性较多,初中、小学文化层次偏多,青壮年、打工者和已婚者居多。

Objective To eliminate Microspironema pallidum by studying the serological test and the message of epidemiology in syphilis. Methods The message of epidemiology in syphilis were provided by syphilis patients from 2005 to 2007 in our hospital. The three serological tests including TRUST , ELISA and TPPA were employed to detect the serum antibodies. Results The morbidity of syphilis was 2.7% in 2005,4.0% in 2006 and 8.7% in 2007. The rate of each staging was 55.9% ,33.8% ,1.5% and 8.8% in 2005, 73.9% ,20.4% ,0.7% and 5.0% in 2006 and 61.3% ,32.1% ,0.6% and 6.2% in 2007. The sensitivity and specificity were 77% and 82% for TRUST, 87% and 95% for ELISA and 68% and 100% for TPPA. The feature of epidemiology indicated that there was a significant difference in male female ratio, civilization, age distribution, occupation and marriage. Conclusion There were significant higher sensitivity for ELISA and higher specificity for TPPA among the three tests. And there was a significant difference in male and female ratio, civilization, age distribution, oeeupation and marriage.