0.05%地奈德乳膏治疗三种常见皮肤病的疗效观察

Comparison of the Efficacy and Safety of 0.05% Desonide Cream in Patients with Three Common Dermatoses

目的评价0.05%地奈德乳膏治疗特应性皮炎、脂溢性皮炎及寻常性银屑病的临床疗效及安全性。方法采用开放式研究。分别应用0.05%地奈德、1%丁酸氢化可的松及0.1%糠酸莫米松乳膏治疗特应性皮炎、脂溢性皮炎及寻常性银屑病。对患者治疗前后红斑、糜烂、浸润、丘疹、渗出/结痂、瘙痒及皮损面积的总积分进行评价。结果治疗2周后,地奈德组的临床疗效明显优于丁酸氢化可的松组,差异有显著性(P<0.05),两组均未见明显不良反应;地奈德组的疗效与糠酸莫米松组相当(P>0.05),但后者有1例出现瘙痒,1例出现红斑加重。结论应用0.05%地奈德乳膏治疗特应性皮炎、脂溢性皮炎及寻常性银屑病疗效可靠,临床使用安全。

Objective To evaluate the efficacy and safety of 0.05% desonide cream in the treatment of patients with three com- mon dermatoses dermatitis. Methods Three hundred and five patients with atopic dermatitis, seborrheic dermatitis and psoriasis vulgaris were entrolled into the open clinical trail. They were divided to receive 0.05% desonide cream, 1% hydrocortisone butyrate ointment and 0.1% mometasone furoate cream. The efficacy was determined by measuring the total scores of erythema, erosion, infiltration, papule, exudation/crust, pruritus and the extent of lesions. Results At the end of the 3 weeks study, the total clinical effective rate in the desonide group was superior to the hydroeortisone butyrate group, with a significant difference between the two groups （P 〈 0.05 ） . No adverse effect related to the drug was found in both groups. The total clinical effective rate in the desonide group was comparable to the mometasone furoate group. However, a case presented with erythema and another case arised pruritus in the mometasone furoate group. Conclusion 0.05% desonide cream is effective and safe for patients with common dermatoses.