摘要
转变生长因素贝它(发信号的 TGF- 尾)/bone morphogenic 蛋白质(BMP ) 涉及绝大多数细胞的过程并且在所有 metazoans 的全部生活期间是根本上重要的。TGF- 尾 / BMP 活动的解除管制几乎总是导致发展缺点或疾病，包括癌症。TGF- 尾 / BMP 小径的合适的工作与另外的发信号的小径取决于它的组成、广泛的通讯，导致 synergistic 或对抗效果和最后理想的生物结果。如此的发信号的串音的性质是压倒性地复杂的并且高度上下文依赖者。这里，我们考察在 TGF- 尾 / BMP 和激活 Mitogen 的蛋白质 kinase， phosphatidylinositol-3 kinase/Akt， Wnt，刺猬，槽口，和 interleukin/interferon-gamma/tumor 坏死 factor-alpha 的发信号的小径之间的串音的不同模式 cytokines，与内在的分子的机制上的一个重音。
Transforming growth factor-beta （TGF-β）/bone morphogenic protein （BMP） signaling is involved in the vast majority of cellular processes and is fundamentally important during the entire life of all metazoans. Deregulation of TGF-β/ BMP activity almost invariably leads to developmental defects and/or diseases, including cancer. The proper functioning of the TGF-β/BMP pathway depends on its constitutive and extensive communication with other signaling pathways, leading to synergistic or antagonistic effects and eventually desirable biological outcomes. The nature of such signaling cross-talk is overwhelmingly complex and highly context-dependent. Here we review the different modes of cross-talk between TGF-β/BMP and the signaling pathways of Mitogen-activated protein kinase, phosphatidylinositol-3 kinase/ Akt, Wnt, Hedgehog, Notch, and the interleukin/interferon-gamma/tumor necrosis factor-alpha cytokines, with an emphasis on the underlying molecular mechanisms.
