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tau蛋白和退行性神经病变 被引量：5

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作者 张明明 何美霞 华海婴
机构地区 郑州大学医药科学研究院 河南省医药科学研究院药理研究室
出处 《中国老年学杂志》 CAS CSCD 北大核心 2009年第2期251-253,共3页 Chinese Journal of Gerontology
基金 河南省科技厅资助项目(072103810403) 河南省卫生厅资助项目(200702009)
关键词 TAU蛋白 tau蛋白病 过度磷酸化 退行性神经病变
分类号 R742 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献19

  • 1Sergeant N, Bretteville A, Hamdane M, et al. Biochemistry of tau in Alzheimer's disease and related neurological disorders [ J ]. Expert Rev Proteomics,2008 ; 5 (2) :207 -24.
  • 2Boeve BF, Hutton M. Refining frontotemporal dementia with parkinsonism linked to chromosome 17 :introducing FTDP-17 (MAPT) and FTDP-17 ( PGRN ) [ J ]. Arch Neurol,2008 ;65 (4) :460-4.
  • 3Jellinger KA. Neuropathological aspects of Alzheimer disease, Parkinson disease and frontotemporal dementia [ J ]. Neurodegener Dis, 2008 ; 5 ( 3- 4) :118-21.
  • 4Ballatore C, Lee VM, Trojanowski JQ. tau-mediated neurodegeneration in Alzheimer's disease and related disorders[ J ]. Nat Rev Neurosci ,2007;8 (9) :663-72.
  • 5Perez M, Santa-Maria I ,Tortosa E, et al. The role of the VQIVYK peptide in tau protein phosphorylation [ J ]. J Neurochem, 2007 ; 103 ( 4 ) : 1447- 60.
  • 6Liu Y, Liu F, Iqbal K, et al. Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease [ J ]. FEBS Lett,2008 ;582(2) :359-64.
  • 7Deng Y, Li B, Liu F,et al. Regulation between O-GlcNA cylation and phospborylation of neurofilament-M and their dysregulation in Alzheimer disease[ J]. FASEB J,2008 ;22 ( 1 ) :138-45.
  • 8Terwel D, Lasrado R, Snauwaert J,et al. Changed conformation of mutant tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of tau-4R/2N transgenic mice[J]. J Biol Chem,2005 ;280(5 ) :3963-73.
  • 9Maeda S, Sahara N, Saito Y, et al. Granular tau oligomers as intermediates of tau filaments [ J ]. Biochemistry,2007 ;46 ( 12 ) :3856-61.
  • 10de la Torte JC. Pathophysiology of neuronal enemy crisis in Alzheimer's disease[J]. Neurodegener Dis,2008 ;5 ( 34 ) : 126-32.

同被引文献46

  • 1LIAO Xiaomei ZHANG Yingchun WANG Yipeng WANG Jianzhi.The effect of cdk-5 overexpression on tau phosphorylation and spatial memory of rat[J].Science China(Life Sciences),2004,47(3):251-257. 被引量：8
  • 2褚文政,钱采韻.侧脑室注射链脲霉素引起大鼠脑Aβ_(1-40)和Aβ_(1-42)表达增加[J].第四军医大学学报,2005,26(15):1356-1358. 被引量：6
  • 3Wang YP Wang XC Tian Q Yang Y Zhang Q Zhang JY Zhallg YC Wang ZF Wang Q Li H Wang JZ.Endogenous overproduction of beta-amyloid induces tau hyperphosphorylation and decreases the solubility of tau in N2a cells.[J].中国生物学文摘,2006,20(9):17-17. 被引量：5
  • 4Sussmuth SD, Tumani H, Ecker D, et al. Amyotrophic lateral sclerosis:disease stage related changes of tau protein and S100 beta in cerebrospinal fluid and creatine kinase in serum[J]. Neurosci Lett,2003,353(1) :57-60.
  • 5Strong MJ, Yang W, Strong WL, et al. Tau protein hyperphosphorylation in sporadic ALS with cognitive impairment[J]. Neurology, 2006,66 (11 ) : 1770-1771.
  • 6Paladino P,Valentino F,Piccoli T,et al. Cerebrospinal fluid tau protein is not a biological marker in amyotrophic lateral sclerosis[J]. Eur J Neurol,2009,16(2) :257-261.
  • 7Conrad C, Vianna C, Freeman M, et al. A polymorphie gene nested within an intron of the tau gene: implications for Alzheimer' s disease[J]. Proc Natl Acad Sci USA, 2002, 99 (11) :7751-7756.
  • 8Glatz DC,Rujescu D, Tang Y,et al. The alternative splicing of tau exon 10 and it s regulatory proteins CLK2 and TRA2- BETA1 changes in sporadic Alzheimer's disease [J]. J Neurochem, 2006,96 (3) : 635-644.
  • 9Levecque C, Elbaz A, Clavel J, et al. Association of polymorphisms in the Tau and Saitohin genes with Parkinson's disease[J]. J Neurol Neurosurg Psychiatry, 2004,75 (3) : 478- 480.
  • 10Jankovic N, Kecmanovic M, Dimitrijevic R, et al. HD phenocopies-possible role of Saitohin gene[J]. Int J Neurosci, 2008,118(3):391-397.

引证文献5

二级引证文献18

中国老年学杂志
2009年 第2期

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