水通道蛋白与肺腺癌

Aquaporins and lung adenocarcinoma

肺癌是人类高发的恶性肿瘤，病死率在恶性肿瘤中居首位。其中，肺腺癌易发生远处转移，而目前肿瘤转移的确切机制不十分明确。最近发现水通道蛋白（aquaporin，AQP）参与细胞迁移和增殖，提示其在肿瘤生物学中的重要作用。已有研究发现，多种AQP在不同来源的恶性肿瘤中高表达，并通过促进血管新生及快速转运水分，在肿瘤细胞的迁移侵袭中起重要作用。目前国内外已有研究发现AQP1、3、5在肺腺癌细胞中高表达。深入研究肺腺癌及肺腺癌转移灶中AQP的表达可能给肿瘤细胞转移机制带来新的视角，并为将来用AQP抑制剂治疗肺腺癌、降低它的侵袭能力和远处转移提供理论依据。

Lung cancer is the leading cause of cancer mortality in the world and one of the top incidence of cancers. Lung adenocarcinoma tends to have distant metastasis, but the mechanism of tumor metastasis is unclear. Recently, it is shown that aquaporin （AQP） is involved in cell migration and proliferation,and AQP plays key roles in tumor biology. Some researches show AQP is highly expressed in tumor cells of different origins, and plays key roles in tumor cells migration through facilitating tumor angiogenesis and making water flow across plasma membrane rapidly. Present studies show AQP1,3,5 are highly expressed in lung adenocarcinoma cells. Knowledge about AQP expression of lung adenocarcinoma and metastasis sites will bring a new sight in the mechanism of tumor metastasis. AQP expression in lung adenocarcinoma facilitates tumor growth and spread,suggesting AQP inhibition as a novel antitumor therapy in future.