运动神经元病的腓肠神经病理形态和定量分析

Sural Nerve Morphometrics of Motor Neuron Disease

目的探讨运动神经元病(MND)的腓肠神经活检病理改变。方法对22例肌萎缩侧索硬化患者进行腓肠神经活检,并采集横断面病理图像,进行定量形态学分析。结果腓肠神经可见有髓纤维密度减低,以大纤维减少为主,薄髓纤维增多。结论MND患者的感觉神经病理形态学存在异常。

Objective To investigate the pathological features of sural nerve biopsy in patients with motor neuron disease （MND）. Methods 22 patients with amyotropbic lateral sclerosis （ALS） underwent sural nerve biopsy and routine electropbysiological examination. The transected images were captured and morphometrically analyzed. Results The myelinated fiber density decreased in ALS patients＂ sural nerves, and larger fibers were involved mostly. The thinly myelinated fibers increased. Conclusion The sural nerves of ALS patients shows mild but definite pathological changes.