低分子量肝素对胸腰椎爆裂骨折后路手术出血量的影响

Influence of Low Molecular Weight Heparin on Perioperative Bleeding after Rear Operation of Thoracolumbar Spinal Bursting Fracture

目的观察胸腰段爆裂骨折合并脊髓损伤行后路内固定手术,应用低分子量肝素预防深静脉血栓时,在围手术期对手术出血量的影响。方法将行胸腰段爆裂骨折合并脊髓损伤后路手术的120例患者分为观察组(64例)和对照组(56例)。观察组皮下注射低分子肝素钠预防深静脉血栓形成,对照组不应用。结果观察组术中、术后出血量,总输血量以及手术前后红细胞计数、血红蛋白含量的变化和对照组比较无显著性差异。结论围手术期应用低分子量肝素不会增加胸腰段后路手术的出血量,以其预防深静脉血栓形成是安全的。

Objective To study the influence of bleeding after using low molecular weight heparin （LMWH） to prevent deep vein thrombosis （DVT） in patients with thoracolumbar spinal bursting fracture and spinal cord injury operated by rear internal fixation. Methods 120 cases were divided into the observation group （64 cases） and control group （56 cases）. The observation group accepted hypodermic injection of LMWH to prevent DVT, while the control group did not. Results The volume of bleeding and blood transfu- sion, the change of red blood cell count （RBC） and hemoglobin were compared between two groups before and after operation. There is no statistical significance. Conclusion During the period of the operation of rear internal fixation, low molecular weight heparin cannot increase the bleeding and is safe to prevent deep vein thrombosis.