脑白质病变与动脉粥样硬化的相关性分析

Correlation between Leukoencephalopathy and Atherosclerosis

目的研究脑白质病变与动脉粥样硬化的关系。方法选择238例神经内科住院患者,根据患者入院后脑MRI分析脑白质损害程度及脑内软化灶,并用多功能超声检查颈部及股部血管斑块、内-中膜厚度、收缩期峰值血流速度。用SPSS13.0统计软件进行线性相关性分析。结果脑白质病变与年龄、高血压、动脉粥样硬化程度、颈总动脉内-中膜厚度成正相关,与颈总动脉的收缩期峰值血流速度成负相关,而与后循环的血流无关。结论脑白质病变与动脉粥样硬化的某些危险因素及动脉粥样硬化程度、慢性脑缺血有关,脑白质损害与前循环损害有关,而与后循环损害无关。

Objective To investigate the correlation between leukoencephalopathy and atherosclerosis. Methods 238 patients were enrolled. All the patients were underwent brain MRI and carotid and femoral artery duplex ultrasonography after hospitalized. The atherosclerotic plaque, intima-media thickness （IMT）, peak systolic velocity （Vp） were measured with ultrasonography. The data was analyzed with SPSS 13.0 software. Results The leukoencephalopathy of the patients positively correlated with age, hyper tension, serious of atherosclerosis and carotid IMT, negatively correlated with carotid Vp, but did not correlated with vertebrarterial Vp. Conclusion The leukoencephalopathy positively correlate with some atherosclerotic risk factors, the serious of atherosclerosis, and anterior circulation disorder, but do not correlate with posterior circulation.