膜增殖性肾小球肾炎9例临床病理分析

Clinical Pathology Analysiy of 9 Cases of Membranoproliferative Glomerulonephnitis

目的：分析9例经肾穿刺活检诊断为膜增殖性肾炎患者临床及病理特点，提高对该病临床及病理诊断方面的认识。方法：回顾1998年9月～2008年9月237例肾穿刺活检病例中诊断为膜增殖性肾小球肾炎9例患者，对其临床表现、光镜病理、电镜病理、免疫荧光病理特点进行总结和分析。结果：9例膜增殖性肾小球肾炎患者占肾穿刺活检总病例数的3．7％，男女性别比为8：1。年龄最小为18岁、最大57岁，平均年龄为39．3岁。以肾病综合征伴血尿、高血压为其主要临床特点。平均随访时间25个月。部分缓解3例，无效2例，恶化4例（进入透析）。结论：膜增殖性肾炎是一种发病率不高的肾小球疾病。临床主要表现为肾病综合征伴肾炎综合征，病理表现有其特殊性。

Objective：Analyze clinical manifestations and pathological features of nine patients which have fallen clown with Membranoproliferative Glomerulonephnitis（MPGN）depending on a Kidney biopsy in order to improve clinical and pathological diagnosis. Methods：A review of 9 cases with MPGN diagnosed througn a kidney biopsy among 237 cases from September , 1998 to September, 2008. To sum up clinical manifestations, their light microscopy pothologies , electron miseroscopy pathologies and immunofluorescence pathologies to analyzed. Results： 9 eases of MPGN was 3.7 % among 237 cases diagonsed by a kidney biopsy Male to female was 8 to 1. The youngest pationt was 18 years old, The oldest one was 57 nyears old , Patients＇ average age was 39.3 years old, The mainfeature is Nephrotic Syndrome with hematuria and high blood pressure , The average follow - up period was 25 months Partial remission was 3 cases, inefficiency was 2 cased, deteriorationwas 4 cases. Conclusion： MPGN was a low incidence of renal glomerular disease, The main clinical manifestation was Nephrotic Syndrom a campamied bynephiritic syndrome. Its pathological manifestation had its own specificness.