西米替丁灌胃预防危重病昏迷患儿应激性溃疡出血的观察及护理

Observation and nursing of cimetidine in preventing stress ulcer hemorrhage of children with exanimation state

目的探讨西米替丁灌胃预防危重病昏迷患儿应激性溃疡出血的临床疗效及护理措施。方法将112例危重患儿随机分为西米替丁组(59例)和对照组(53例)。西米替丁组加用西米替丁每天10～15mg/kg,分3次经胃管灌入,连用5d。结果西米替丁预防组昏迷患儿应激性溃疡出血的发生率(11.32%),明显低于对照组(47.22%),χ2=8.21,P(0.01。结论西米替丁灌胃能有效预防应激性溃疡出血的发生,且副作用少。

Objective To discuss the efficacy and nursing methods of cimetidine prevents stress ulcer hemorrhage in children with exanimation state. Methods One hundred and twelve cases of children with crisis diseases were randomly divided into cimetidine group （59 cases） and control group （53 cases）. Cimetidine group received cimitidine 10 - 15 mg· kg^-1·d^- 1, tid, ip, for 5 d. Results The morbidity of stress ulcer hemorrhage was 11.32% in cimetidine group and 47.22% in control group, respectively （P 〈 0.01 ）. There were no obviously adverse reactions. Conclusions Cimetidine is effective in preventing stress ulcer hemorrhage of children with exanimation state.