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Aurora-A基因的研究进展

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摘要 Aurora—A是Aurora激酶家族的重要成员．是新近发现与细胞有丝分裂密切相关的基因．是调节中心体、微管功能的丝／苏氨酸激酶，在有丝分裂的正常进行中发挥至关重要的作用。它可引起中心体扩增。染色体的不稳定．非整倍体的形成而导致肿瘤的发生。现综述近年来Aurora—A的研究进展。
作者 张志宏 舒勇
机构地区 南昌大学第一附属医院
出处 《江西医药》 CAS 2008年第12期1428-1431,共4页 Jiangxi Medical Journal
关键词 A基因 细胞有丝分裂 苏氨酸激酶 中心体扩增 非整倍体 染色体
分类号 R394 [医药卫生—医学遗传学] R758.63 [医药卫生—皮肤病学与性病学]
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参考文献21

  • 1Dutertre S,Descamps S,and Prigent C.On the role of aurora-A in centrosome function.Oncogene, 2002,21 (40):6175
  • 2Hannak E,Kirkham M,Hyman AA,et al.Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans.J Cell Biol, 2001,155(7):1109
  • 3Giet R ,McLean D,Descamps S,et al.Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules.J Cell Biol,2002,156(3):437
  • 4Berdnik D,Knoblich JA.Drosophila Aurora-A Is Required for Centrosome Maturation and Actin-Dependent Asymmetric Protein Localization during Mitosis.J Curr Biol,2002,12:640
  • 5Meraldi P,Honda R,Nigg EA.Aurora A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- 2 cells.EMBO J,2002,21(4):483
  • 6Dutertre S,Descamps S,Prigent C,et al.On the role of aurora A in centrosome function. Oncogene,2002,21 (40):6175
  • 7Dutertre S,Cazales M,Quaranta M,et al.Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-Mtransition.J Cell Sci,2004,117(Pt 12):2523
  • 8Tsai MY,Wiese C,Can K, Martin O,Donovan P,Ruderman J,Prigent C and Zheng Y. A Ran signaling pathway mediated by the mitotic kinase Aurora A in spindle assembly.J Nat Cell Biol,2003,5:242
  • 9Eyers PA,Erikson E,Chen LG and Mallet JL. A novel mechanism for activation of the protein kinase aurora A.J Curr Biol,2003,13:691
  • 10Satinover DL, Leach CA,Stukenberg PT,et al. Activation of Aurora-A kinase by protein. Proc Natl Acad Sci USA,2004,101(23):8625

二级参考文献25

  • 1邹丽娟,李国权,宫琳琳,汪洋,金伟,赵瑾瑶,马海英,杨佩满,邵淑娟.Aurora-A激酶在人类不同肺癌细胞株中的表达[J].癌症,2005,24(7):792-795. 被引量：6
  • 2Mahadevan D, Bearss D J, Vankayalapati H, Structure-based design of novel anti-cancer agents targeting aurora kinases[ J]. Curr Med Chem Anticancer Agents, 2003, 3 ( 1 ) : 25-34.
  • 3Hamada M, Yakushijin Y, Ohtsuka M, et al. Aurora2/BTAK/STK15 is involved in cell cycle checkpoint and cell survival of aggressive non-Hodgkins lymphorna[ J ]. Br J Haematol, 2003, 121 (3) : 439-447.
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  • 7Bischoff JR, Aanderson L, Zhu Y, et al. A homologue of drosophila aurora kinase is oncogenie and amplified in human colorectal cancers[ J]. EMBO J, 1998, 17 ( 11 ) : 3052-3065.
  • 8Durerere S, Descamps S, Priget C. On the role of aurora-A in centrosome function[ J]. Oncogene, 2002, 21 (40) : 6175-6183.
  • 9Salcakura C, Hagiwara A, Yasooka R, et al. Tumour-amplified kinase BTAK is amplified and overexpression in gastric cancers with possible involvement in aneuploid fomation[ J]. Br J Cancer,2001, 84(6) : 824-831.
  • 10Li D, Zhu J, Firozi PF, et al. Overexpression of oncogenie STK15/BTAK/Aurora-A kinase in human pancreatic cancer[ J].Clin Cancer Res, 2003, 9(3): 991-997.

共引文献3

江西医药
2008年 第12期

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