摘要
以2-氨基-4-硝基苯甲酸和甲酰胺为原料,经Niementowski、氯代、烃化反应合成4-苯基氨基-7-硝基喹唑啉盐酸盐,再经铁粉还原得4-苯基氨基-7-氨基喹唑啉。目标化合物的结构经1HNMR、IR、MS谱表征。前三步反应采用微波辐助合成,大大缩短了反应时间,提高了反应速率和收率。
A microwave-assisted preparation method of the protein tyrosine kinase inhibitors aniline quinazoline was reported. 4-Anilino-7-nitroquinazoline hydrochloride salt was synthesized using 2-amino-4-nitro benzoic acid as the starting material through the Niementowski reaction, chlorination and alkylation, and then gave the target product through iron reduction reaction. The structure of the target compound was confirmed by ^1H NMR, IR and MS. The microwave-assisted synthesis method in the former three-step reactions can not only reduce reaction time, but also increase the reaction rate and yield of product.
出处
《精细化工中间体》
CAS
2008年第6期25-26,40,共3页
Fine Chemical Intermediates
基金
广东省自然科学基金资助项目(04009620)。
