微波辐射合成对叔丁基苯甲酸

Synthesis of p-Tert-butylbenzoic Acid with Microwave Irradiation

用对叔丁基甲苯(PTBT)为原料,高锰酸钾为氧化剂,季铵盐为相转移催化剂,采用微波辐射技术合成对叔丁基苯甲酸(PTBA)。考察了反应物的配比、微波辐射功率、反应时间等因素对反应收率的影响,得到反应的优化条件:n(对叔丁基甲苯)∶n(高锰酸钾)=1∶1.5,微波辐射功率660W,反应时间为50min,收率可达82.6%。其结构经IR和1HNMR确证。

p-Tert-butylbenzoic acid was synthesized using p-ten-butyl toluene as material, potassium permanganate as the oxidant and quaternary ammonium salts as phase transfer catalyst under microwave irradiation. Various factors that influenced the reaction were studied. The optimum conditions were determined as follows： the molar ratio of p-tert- butyl toluene and potassium permanganate was 1：1.5, the microwave irradiation power was 660 W, the reaction time was 50 min, under the optimal conditions, the yield of product was 82.6%. The structure of products weas confirmed by IR and IH NMR .