成人喉乳头状瘤超微病理研究

Ultrastructural pathologic research on the adult laryngeal papilloma

为探讨成人乳头状瘤超微病理特征，采用扫描和透射电镜观察9例成人喉乳头状瘤。结果：该肿瘤呈息肉样分叶状外观，表面被覆形态不一的短、粗状微绒毛。肿瘤细胞生长活跃，棘细胞层明显增厚。基底细胞与结缔组织界面结构有改变，其随肿瘤细胞异型性的增加而增大。当基底膜及半桥粒结构明显改变时，提示该肿瘤具有侵袭件。

In this paper, the ultrastructural featuers of laryngeal papillomas of 9 cases of adult patients were investigated by means of SEM. It showed that the polypoid surface of the papilloma is easily recognized; the surface cells are covered by microvilli of different size and shape; and the epithelium is bordered by an irregular and continuous basement membrane. In some areas,there is pseudopodium of basal cells stretching into connective tissue. The structure of interface betweep basement membrane and connective tissue varies with aggravation of tumor cell atypia. The significant variation of structural of basement membrane and semidesmosomes suggests the possibility of malignant change.