旋复代赭汤加味防治恶性肿瘤化疗呕吐反应的临床研究

Clinical Study on Preventing and Treating Chemotherapy Induced Nausea and Vomiting Using Supplemented Inula Ochrae Decoction

目的 :观察旋复代赭汤加味防治恶性肿瘤化疗的恶心呕吐反应。方法 :72例患者用旋复代赭汤加味治疗 ,同时设西药恩丹西酮为对照 ,对化疗呕吐反应的防治效果进行前瞻性临床自身交叉对照研究。结果 :中药组对顺铂化疗与非顺铂化疗的止呕有效率分别为92 7%、93 5 % ,高于西药对照组的 87 8%、87 1 % ,但无统计学意义。结论 :该方能有效防治恶性肿瘤患者化疗的恶心呕吐反应 ,有临床推广价值。

Objective: To observe supplemented Inula Ochrae Decoction (SIOD) in preventing and treating nausea and vomiting induced by chemotherapy for patients with malignant tumour. Methods: Seventy two patients were divided into two groups, the patients in test group took SIOD and in control group using ondensetron, and the efficacy of SIOD in preventing and treating chemotherapy induced nausea and vomiting were studied prospectively with self intersection approach. Results: The effective rate of treating vomiting due to chemotherapy with DDP and without DDP in the test group was 92.7% and 93.5% respectively, and was higher than that in the control group 87.8% and 87.1%, the difference was insignificant statistically (P>0 05).Conclusions: The prescription SIOD could prevent and treat effectively chemotherapy induced nausea and vomiting without any toxic and side effects, and is inexpensive with high efficacy for clinical use.